Our lab is interested in understanding the molecular events that regulate the maturation of immune cells called lymphocytes. This process is central to the immune system as it generates the immune cells that control disease-causing pathogens and generate protective immunity, such as after vaccination.
My research focuses on understanding the transcriptional regulation of lymphocyte differentiation, in particular the role of transcription factors in effector and memory T and B cell commitment. My work uses genetic models and cell culture systems. Current studies focus on Blimp1, IRF4 and other transcription factors in the differentiation of regulatory and conventional T cells and during B cell lymphoma development. Epigenetic and metabolic regulation of lymphocyte differentiation are new research avenues in my lab.