Carola Vinuesa’s research aims to unravel the complex interaction of cells and molecules that regulate the production of potent, long-lasting antibody responses and to identify genetic abnormalities that interfere with this process and contribute to the development of autoimmunity.
Her group has identified genes, cell types and checkpoints important to prevent autoantibody-mediated diseases. Her team is also working towards connecting genetic variation in humans to autoimmune disease with the goal of identifying more targeted treatments. She directs the Centre for Personalised immunology (CPI), an NHMRC Centre for Research Excellence that is sequencing whole genomes from patients with immune-mediated diseases to uncover mutations that cause disease. She also co-directs the China Australia Centre for Personalised Immunology (CACPI) based in Shanghai Renji Hospital (Jiaotong University). The ultimate aim of her research is to understand autoimmune disease pathogenesis, refine diagnosis and develop improved approaches to therapy.